Enhancing Sustainability of Global Society Through Jitsugaku (Science), Keio University’s plan selected for the 2014 Top Global University Project, follows the founding principles of the university. Keio aims to integrate research in the humanities and sciences to enhance the sustainability of global society through jitsugaku (science), and to strengthen ties with international academic communities and industry, while making positive contributions to the world and bolstering its international reputation by building on Keio’s strengths and achievements. Specifically, under the integrated theme of Sustainable Development of a Super Mature Society, Keio will create three main clusters: Longevity, Creativity, and Security. Keio will establish a permanent Super Global Project Head Office, bring together all available resources in the university to each cluster, and dramatically increase the number of English-language papers cited by scholars globally, and collaborative papers jointly authored with international researchers. Furthermore, in addition to creating this cluster system, Keio will improve its human resources management system (cross appointment system, tenure-track system, annual salary system, etc.); broadly expand its education system (overseas associate supervisor system, English-based degree programs, etc.); bring more of Keio research onto the global stage; and enhance Keio’s international presence in education and research, measured by the number of citations and world-wide reputation surveys. Additionally, in order to reinforce the President’s leadership and governance, Keio will establish the Global Advisory Council, as well as a discretionary fund that the President can distribute swiftly and flexibly in order to accelerate reform. Presidential leadership will promote new initiatives in Keio University’s endeavors to becoming one of the world’s leading research institutions.